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Drug Interactions Drug interactions show low risk with most medications but notable considerations include: Zinc supplements: Compete with copper absorption, may affect copper metabolism and GHK-Cu efficacy Birth control pills: Can affect copper metabolism and levels Certain antibiotics: Some may affect copper absorption/utilization Copper-chelating medications: Directly antagonistic to GHK-Cu, should not be used concurrently Copper Overload Realistic Assessment Theoretical concerns about copper toxicity contrast sharply with actual risk at recommended doses

The sequences for the short hairpin RNAs (shRNAs) targeting EPAS1 and HIF-1A genes and the negative control were as follows: ShCTR : 5- TTCTCCGAACGTGTCACGT-3 (CDS region)

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