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HIF-1 has also been implicated, particularly in mice, where it has been linked to reduced activity of the PI3K/Akt pathway, an essential signaling axis for the activation of myogenic factors [108]

CJC-1295 is a GHRH analog studied at the GHRH receptor, while ipamorelin is a selective ghrelin-receptor agonist, a GHRP, studied at the GHS-R or ghrelin receptor