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In particular, it has been demonstrated that zinc oxide nanoparticles significantly increased oxidative stress in 3T3-L1 adipocytes in a dose-dependent manner [64], although increasing the expression of antioxidant enzymes [65]

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In PD, folate deficiency and hyperhomocysteinemia worsen motor deficits and nigral dopaminergic loss, with mechanistic links to glutathione depletion, mitochondrial dysfunction, oxidative stress and NLRP3-mediated inflammation [82, 171]

Oct 2018;110(5):794-809

Mukhopadhyay S, Encarnacin-Rosado J, Lin EY, Sohn ASW, Zhang H, Mancias JD, et al