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FIGURE 1 The levels of cellular nutrients (amino acids, glucose, certain lipids, and likely other metabolites) are sensed and signaled by an expanding number of proteins (SESNs, CASTOR, KICSTOR, SAMTOR, GATOR1 and 2) (Saxton and Sabatini, 2017) that culminate in the control of the guanosine phosphate state of the members of the Rag family of GTPases, which bind mTORC1 in a nutrient-sensitive manner (Figure 1)

Acta Physiol Scand 182:321331 Sullivan PG, Rippy NA, Dorenbos K, Concepcion RC, Agarwal AK, Rho JM (2004) The ketogenic diet increases mitochondrial uncoupling protein levels and activity

Abstract Systemic lupus erythematous (SLE) is a multisystem chronic autoimmune disease in which disrupted molecular pathways lead to multiple clinical manifestations

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doi: 10.1182/blood-2002-07-2283 204 XueLQiHZhangHDingLHuangQZhaoDet al