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ATP initiates revitalization of APCs, which in turn stimulates P2X7 receptors on APCs, increasing expression of CD86 through P2X7-gated Ca2+ influx and activating T cells ultimately [143]

doi: 10.1186/s11658-022-00381-1 289 LiuZGuoHZhiYJiangXZhangQ

When the IN administration of risperidone-loaded mucoadhesive nanoemulsion was compared to the intravenous delivery of risperidone nanoemulsion in Swiss albino rats, it was observed that the IN method led to enhanced efficacy, improved brain targeting, and increased drug transport to the brain