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Am J Gastroenterol 107(9):13801387 Bjrnsson ES, Hoofnagle JH (2016) Categorization of drugs implicated in causing liver injury: critical assessment based on published case reports

(2019) systematically analyzed the metabolism of 271 orally administered drugs by 76 species/strains of human intestinal bacteria, identified bacterial genes and their products involved in drug metabolism, and validated some of the findings in mouse models and human gut microbiota cultures, deepening the understanding of the molecular mechanisms involved in drug metabolism by gut microbiota and providing insights into individualized drug interventions targeting microbiota

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