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8 Where results are unclear, serum MMA and homocysteine levels (both of which accumulate with B12 deficiency as discussed above) can also be used to confirm a diagnosis, although homocysteine is not specific to B12 deficiency, as it may also be caused by deficiencies in other B vitamins

Ongoing inflammatory conditions can affect B12 status

We obtained the physical functioning sub-scale from the Rand 36 questionnaire, along with the fatigue and concentrations scores from the CIS20r questionnaire

Norris J

Today, Vitamin B12 deficiency is a commonly encountered clinical diagnosis and most clinicians will have prescribed B12 replacement therapy for some of their patients