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As a new oral drug for UC treatment, JAK inhibitor acts on signal transduction in cells and reduces the production and signaling of downstream cytokines, thus down-regulating immune response and alleviating intestinal inflammatory reaction (56)

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L-methionine, another sulfur-containing amino acid, further supports this pathway and is a critical component of Phase II liver detoxification

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TMT reporter ion intensities were normalized to the median summed signal intensity across channels, and the data were filtered to retain proteins with at least two distinct peptides