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Early studies have found that the brains of people with PD, AD, MS and mild cognitive impairment (MCI), exhibit high levels of oxidative damage, including mitochondrial dysfunction, DNA and protein damage, lipid peroxidation, and myelin injury [62, 63]

Results tRF levels in CSF show PD-specific changes To seek PD-characteristic tRF profiles, we analyzed a short RNA sequencing (RNA-seq) dataset (phs.000727) 38 consisting of postmortem (PM) CSF samples from 46 patients with PD, from 53 patients with Alzheimers disease (AD) and from 53 healthy controls (15, 27 and 24 females, respectively