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Autologous HSCT should be considered as the first choice for eligible patients achieving second molecular remission (undetectable MRD in the BM).7,108,109 However, a recent report questions the role of transplantation, at least in patients achieving molecular remission with ATO and ATRA who do not have CNS disease at relapse and who have received a full course of consolidation with ATO.33 Chakrabarty et al.110 reported on 294 patients who received either allogeneic transplant (n = 232) or autologous transplant (n = 62) between 1995 and 2006