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Description

CAECAL LIGATION AND PUNCTURE An experimental model of peritonitis in rodents, in which the caecum is ligated and then punctured, thereby forming a small hole

The study did not establish causation, but the event illustrates why small trials cannot be described as proof of safety

In vivo, LCN2 inhibition significantly reduced severe ischemia-induced tubular injury, suppressed lipid peroxidation (MDA), restored glutathione levels (GSH), and alleviated iron overload (Fe 2+ ) and reactive oxygen species (ROS)