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PMID 14527323

Table: Comparison of Vitamin B12 Administration Methods The 2000 mcg Twice Weekly IM Protocol from Clinical Trials Studies show a 2000 mcg twice weekly IM injection works well for neuropathy

Shi J et al

Additionally, Protein kinase C (PKC) pathway activation can induce insulin receptor substrate 1 (IRS-1) phosphorylation, inhibiting insulin signaling through downstream effectors such as Akt, phosphoinositide 3-kinase (PI3K), and glucose transporter 4 (GLUT-4) (Ritter et al., 2015