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doi: 10.1053/j.gastro.2009.02.077 46 AmedeiACapponACodoloGCabrelleAPolenghiABenagianoMet al

It is important to emphasise that these potential benefits are largely theoretical or extrapolated from separate studies, rather than proven through robust clinical trials of the combination

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However, recent clinical trials have shown conflicting results, as favorable clinical effects have not translated into an overall survival benefit (10)