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Recent research suggests that activated microglia in SCI can release substantial amounts of nitric oxide, which in turn decreases ferritin levels while upregulating the expression of TFR, DMT1, and iron regulatory protein 1 in motor neurons (Feng et al., 2021)

The process can be initiated by elevated glucose or insulin, and liver X receptor A, thereby promoting hepatic lipid accumulation and regulating to lipid-producing genes such as Acetyl-CoA Carboxylase (ACC), Stearoyl-CoA Desaturase-1, and Fatty Acid Synthase (FASN) (Geidl-Flueck and Gerber 2023

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It also plays a role in energy production and it supports mental nourishment.*

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Kondoh H, et al