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Furthermore, compared with PROTACs, molecular glues lack linkers, rendering them favorable drug-like properties, including lower molecular weights, fewer hydrogen bond donors, and fewer rotatable bonds

Similarly, the green fluorescent signals from AsGGT1 N300 -GFP, AsGGT1 Full -GFP, AsGGT3 N300 -GFP, and AsGGT3 Full -GFP were observed in the cytosol, although the fluorescent signal intensities were much weaker (data not shown)

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A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones

2000), several studies have demonstrated good concordance of the assay with the in vivo transgenic rodent (TGR) somatic mutation assay and also high sensitivity of 92.1% (35 out of 38 chemicals correctly identified) for detecting human IARC group 1 and Group 2A carcinogens, comparable to the TGR assay with 90.3% (Kirkland et al