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Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a pandemic disease affecting the respiratory system and also other organs of the human body ( At the cellular level, the structural and functional dysfunction of endothelium is due to the lack of nitric oxide (NO), cellular oxidative stress, the inflammatory process, and a damaged glycocalyx structure

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J Neuroinfect Dis 5:110 Li J-M, Zhao Y, Sun Y, Kong L-D (2020) Potential effect of herbal antidepressants on cognitive deficit: pharmacological activity and possible molecular mechanism

Preclinical evidence shows the significance of microbial metabolites and immune signaling in driving these effects, and recent clinical studies further supports these findings (Touchefeu et al., 2014