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FABP5 plays a key role in retrograde endocannabinoid signaling and acts as a carrier of endocannabinoids at synapses in the central nervous system [36]

Alcohol promotes the nuclear translocation of acetyl-CoA synthetase 2, heightening euchromatic histone lysine methyltransferase 2 acetylation, thereby accelerating fatty acid synthesis and driving hepatic lipid accumulation, ultimately leading to liver damage (Lu et al., 2023b)

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If G12D inhibitors addresses the needs of specific patient populations, Pan-RAS strategy seek to expand therapeutic coverage cross a much broader spectrum of RAS-driven tumors