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5.4.2 Age-related considerations in immunosuppressive therapy Age-specific pharmacotherapy considerations primarily involve pharmacokinetic differences and adverse effect susceptibility (101)

Ann Gastroenterol Surg 4:2129 Liu A, Arbiser JL, Holmgren A, Klein G, Klein E (2005) PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12

Diagnosis relies on B12 levels, methylmalonic acid, homocysteine, and intrinsic-factor antibodies interpreted by a clinician

Interestingly, IR-deficient chondrocytes had increased IGF-1R levels and were more responsive to IGF-1 consistent with the notion that IGF-1/IGF-1R may compensate, at least in part, for loss of IR signaling

2017;8:e2970