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Besides contributing to the increase of tumour mass, the rewiring of cholesterol and sphingolipids metabolism alters the composition of lipid rafts that play an important role in other hallmarks of cancer such as oncogenic signalling, migration, proliferation, adhesion, invasiveness, metastatic spread, apoptosis evasion [51], vesicular trafficking and drug resistance [52]

Razani et al., 2001)

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Historical Perspectives The biological associations and medical implications of free radicals have drawn the attention of researchers since the 1950s

Current evidence also poses challenges due to the heterogeneity of study designs and methodologies