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It is important to understand precisely how the insulin-GLUT4 pathway is perturbed in insulin resistance since insulin resistance is a major risk factor for the development of type 2 diabetes and other metabolic diseases, and there are currently no pharmaceutical interventions that target this pathway directly

GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma

DOI: 10.1111/j.1468-1331.2008.02056.x