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May 21 2024;16(11)doi:10.3390/nu16111550 McNulty H, Pentieva K, Ward M

Retrieved 19 March 2011

The upregulated urea cycle removes -amyloid and ammonia on one hand, while on the other, overproduction of the urea cycle metabolite ornithine leads to the overexpression of the enzyme ornithine decarboxylase 1 (ODC1), which produces excessive putrescine that subsequently degrades into GABA, H 2 O 2 and ammonium (see previous section)