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2020, 6 (16), eaaz6020 10.1126/sciadv.aaz6020

AP5Z1 is a helicase that likely plays a role in the repair of homologous recombination DNA double-strand break 26

The study showed that 8 g PUFA intake daily over 18 weeks was associated with a significant reduction of TNF production in lipopolysaccharide-stimulated peripheral blood mononuclear cells in vitro

Curcumin and its related metabolites inhibit the formation of oxygen radicals and exhibit ROS-scavenging effects, thereby reducing DNA damage ( 5.2.2 Positive effects on various stages of NAFLD Elevated FFAs resulting from excessive dietary fat intake are a key risk factor for fatty liver

For chronic tendon injury, hypervascularity and high levels of VEGF were demonstrated in degenerated human and rabbit Achilles tendons or chronic tendon tendinopathy compared to native tendons ( The negative effect may be attributed to the fact that VEGF also has the potential to stimulate the expression of matrix metalloproteinases (MMPs) and inhibit the expression of tissue inhibitors of metalloproteinases (TIMPs) in endothelial cells and fibroblasts ( The Role of Exogenous Vascular Endothelial Growth Factor Delivery in Tendon Healing Due to the necessity of angiogenesis for tendon repair, some scholars have explored the effect of using the delivery of exogenous VEGF on tendon healing as endogenous VEGF may not be sufficient to enhance early revascularization (Table 1