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It is possible that the EAR motif in BZR1 is involved in interaction with co-activators at the BR-activated promoters, to both mediate gene activation and prevent recruitment of TPL repressor

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Additionally, Alda-1 stimulates esterase activities in both enzyme variants, with a particularly pronounced effect on ALDH2 2*2, where esterase activity increases by 100-fold, compared with a 10-fold increase in wild-type ALDH2 (134)