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Human cystathionine beta-synthase is a target for sumoylation

Under stress or tumor growth, there is an increased need for enzyme breakdown, which leads to formation of dimers or longer oligomers of ChaC1 (20)

By inhibiting adenosine A2A receptor-mediated microglial activation, caffeine may attenuate post-stroke neuroinflammation and reduce secondary neuronal damage (164, 166)

Skin and Other Effects: Very rarely, severe skin rashes or abdominal pain have been reported

Besides well-known oxidants or electrophiles, such as H 2 O 2 , 4-hydroxynonenal, and diethyl maleate (DEM), which also possess cytotoxicity, only few Nrf2 activators have been found to be useful in clinical trials (Sun et al