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Botox: A New Avenue for Migraine Management The concept of using Botox to alleviate migraines stemmed from observations of patients who received Botox injections for cosmetic purposes reporting fewer headaches

At the molecular level, intra-articular delivery of FOXO3 effectively enhanced the collagen marker, Collagen II, in the cartilage

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I treat it as a tool with a strong mechanistic rationale, an excellent safety signal in the studies we have, and a body of evidence that's still maturing on the human side