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Insulin-signaling pathway regulates the degradation of amyloid -protein via astrocytes

We obtained a mutant strain containing the ifd-1(ok2404) deletion (1863 base pairs deleted) and used CRISPR/Cas9 technology to generate deletion allele ifd-2 ( bz187) , which is missing the ifd-2 start codon and the first three ifd-2 exons are affected