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There is also evidence to implicate inflammation

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Next, cell suspensions were prepared and blocked in a 0.3% bovine serum albumin (BSA) solution, incubated with primary antibodies (including PE-CD86, APC-CD206, and FITC-CD11b

The focus of preclinical studies has shifted from investigating glucose metabolism alone to exploring more complex mechanisms, such as the metabolic interplay between Schwann cells and axons and the role of insulin resistance in nerve function