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Glutathione can be recycled through the oxidation/reduction cycle of its reduced (GSH) and oxidized (GSSG) forms 1

1a) is the most prevalent antioxidant in the brain, found in millimolar concentrations in most cells

Hodge S, Matthews G, Mukaro V, et al

Establishment of K7M2-Luc orthotopic osteosarcoma mouse model and therapeutic effect evaluation Tumor model establishment To establish orthotopic model, K7M2 cells (3 10 6 cells/well) were dispersed in PBS buffer and implanted into right tibia of BALB/c mice

To enhance the fluxes to l-cysteine and glycine, we knocked out sdaA to construct the double mutant MG012 by deletion of sdaA in the tnaA mutant MG001