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Targeting ANPEP combined with sorafenib treatment exhibited a greater tumor-inhibitory effect than each individual operation

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In this context, ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a critical role in vascular injury and dysfunction ( Ferroptosis not only contributes to endothelial injury but also amplifies the inflammatory response in sepsis, creating a vicious cycle of vascular dysfunction and systemic inflammation ( In summary, ferroptosis plays a pivotal role in the pathophysiology of sepsis by contributing to endothelial injury, vascular dysfunction, and the amplification of systemic inflammation

Komatsu M., Kimura T., Yazaki M., et al., Steatogenesis in AdultOnset Type II Citrullinemia Is Associated With DownRegulation of PPAR, Biochimica et Biophysica Acta, Molecular Basis of Disease 1852 (2015): 473481, 10.1016/J.BBADIS.2014.12.011