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Other causes Other causes of acute liver failure include ischemic hepatitis, autoimmune hepatitis, Wilson disease, Budd-Chiari syndrome, and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome

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An increase in BUN within the first 24 h is now recognized as a significant risk factor for mortality and is closely associated with multiple organ failure and severe disease progression

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It is suggested that the methionine residue at position 358 in hAAT is sterically exposed and readily oxidized 54