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The pharmacokinetics were compatible with a two-compartment model with a first-order distribution and elimination rate, and pharmacokinetic parameters were not different between the two doses, except for the elimination half-life

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Mice were handled in accordance with the NIH Guide for the Care and Use of Laboratory Animals, and experiments were approved by the Fred Hutch Cancer Center Institutional Animal Care and Use Committee and Institutional Review Boards

These multimodal effects contributed to follicular regeneration and produced outcomes on hair growth comparable to minoxidil

More recently, two studies from the Spielmann laboratory using genetic and proximity ligation approaches have shed further light on this process, revealing that components of a non-canonical endocytic apparatus are involved