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Lapatinib Induces Ferroptosis in Cardiomyocytes by Regulating ATF4/GPX4

5, 5-dimethyl-2, 4-imidazolidinedione

Genetic and metabolic control of the mitochondrial transmembrane potential and reactive oxygen intermediate production in HIV disease

Intracellular iron is stored in two major formsan unstable intracellular free ferrous iron pool and an inert form bound to ferritin ( 2 can trigger the Fenton reaction, producing ROS ( 4.2.2 Iron metabolism Transferrin-bound trivalent iron binds to the transferrin receptor (TFR1), allowing direct cellular entry through endocytosis and converts it to ferrous iron through STEAP3