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ROS production The majority of ROS originate from the mitochondrial electron transport chain (METC)

Conversely, elevated -syn inhibits intracellular trafficking and lysosomal function of normal GCase in neurons, indicating the presence of a bidirectional pathologic loop between GCase and -syn in PD and other synucleinopathies (Aflaki et al

Vitamin B12 is not on that list

In addition, structural modifications, generating analogs, and conjugation for half-life extension, may be important for therapeutic development of MOTS-c [23]