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The potential applications of the EPS, obtained from submerged cultures of P

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

Sexual dimorphism in the 3xTg-AD Mouse model and its impact on pre-clinical research

Since both the Lagrangian and Eulerian approaches assimilate the same set of temperature and salinity observations, the differences in the errors of estimating the 3D temperature and salinity states result from the differences in error covariances related to the Lagrangian positions and the derived Eulerian velocities