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4d), among which six ferroptosis-inhibiting genes (Slc7a11, Slc40a1, Gclm, Fth1, Gclc, and Gss) were upregulated, one ferroptosis-promoting gene (Slc39a14) was downregulated, and one ferroptosis-promoting gene (Hmox1) was upregulated

The European journal of medicine

Conclusions We used a genetic model of primary hemochromatosis, human explanted heart tissue with iron overload and a patient with primary hemochromatosis to reveal convergent pathways of iron-mediated injury and heart disease

Studies also showed that low serum levels of vitamin D and zinc are associated with poor outcomes in patients with COVID-19 (158) and a good vitamin D status may have beneficial effects on the course of the disease (177, 178)

Thioredoxins reduce disulfide bonds in oxidized proteins, converting them back to their functional thiol form (Silva-Adaya et al., 2014)