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Epigenetic Regulation Mediated by BACH1 Many studies have shown that quite a few partner proteins or cofactors bound BACH1 for the epigenetic regulation of BACH1 target gene expression ( Figure 2 )

PD patients were categorized into de novo (dn-PD), early (mild-PD), or moderate (mod-PD) groups according to their clinical evaluation (MDS-UPDRS part III) and time of disease progression (see methods)

Proteins were eluted by boiling the beads in 75 L of 2x SDS sample buffer for 10 minutes

Consistent with its role in promoting lipid peroxidation, treatment with 0.5 M of ML162 significantly elevated BODIPY intensity, and increasing the dose of ML162 to 1 M further enhanced BODIPY intensity (Fig