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The combination of rhodamine organic dyes and luminescent transition metal centers exhibits low cytotoxicity, increases tumor cell uptake, and enhances antitumor efficacy (154)

In addition, ROS contribute to this process

doi: 10.1006/hbeh.1998.1466

52,53 Thus, RAGD preferentially promotes mTORC1 phosphorylation of TFEB, which is linked to a stronger association of RAGD with the lysosome than RAGC, whereas TFE3 is preferentially recruited by RAGC