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10.1073/pnas.0800881105 25 BroertjesJ.KlarenbeekJ.HabaniY.LangeslagM.JalinkK

ROS-induced apoptosis also explains the beneficial effect of two analogs of nuclear receptor ligands in several types of cancer: 2-methoxyestradiol, a 17-estradiol metabolite, and N-(4-hydroxyphenyl) retinamide, a synthetic analog of retinoic acid, have been shown to induce PCD in neuroblastoma and lung cancer cells, respectively 104,105