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Toll-like receptors (TLRs), particularly TLR4, serve as central mediators of innate immune activation through the detection of pathogen- and damage-associated molecular patterns 4

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These integrative approaches combine nutritional optimization, exercise and movement strategies, sleep and circadian rhythm optimization, stress management and psychological wellbeing, targeted supplementation including glutathione, hormone optimization where appropriate, and regular monitoring of health biomarkers and age-related changes