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Bulls-eye rash or erythema migrans on the skin (spot-like) is the early sign of Lyme disease, and is followed by fever, sluggishness, arthralgias, or other neurologic features

However, in addition to neurotoxicity associated with A peptide and pTau, other key determinants of the neurodegenerative process need to be included in the list of the main causative factors of AD

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Cutting edge: selective oral ROCK2 inhibitor reduces clinical scores in patients with psoriasis vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10

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