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In tumor immunity, HDAC inhibitors strengthens the immunogenicity and antigen-presenting capacity of tumor cells by stimulating the natural killer (NK) group 2 member D (NKG2D) signaling pathway.HDAC inhibitors thus promotes the expression of tumor antigens, upregulating MHC class I and II molecules, along with their associated antigen-processing mechanisms, costimulatory molecules, and NK-cell-activating ligands.HDAC inhibitors also reduces NK cell activation and damage to tumor cells

Treatments and therapies

16 While the ideal dose of rasburicase for all patients with TLS is suggested to be a single dose of 6mg, studies indicate that a 3mg dose may be adequate for most cases of hyperuricemia

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In CKD patients, reduced corin expression in the kidney and decreased urinary soluble corin levels have been reported [58] whereas its overexpression in the UUO model attenuated fibrosis progression [59]