The observed threshold effect at 358.7 pg/mL (OR = 1.04 per 10 pg/mL, 95% CI: 1.001.08, P = 0.03) suggests a plateau in B12 benefit beyond this level, likely due to saturation of methionine synthase activitya mechanism consistent with non-linear enzymatic dose-response relationships, where additional B12 may not enhance methylation capacity [21]
By reducing it to dihydrolipoate, dietary -lipoic acid participates in the regeneration of other antioxidants (e.g., vitamins C and E, reduced glutathione), thus being considered an inducer molecule (Johansen et al., 2005)
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AHRQ publication no
Store tightly closed, in a cool, dry place, away from sunlight and heat
