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Haghi et al

The pattern did not clearly extend to regular alpha-ketoglutarate

Clinical pattern, mutations and in vitro residual activity in 33 patients with severe 5, 10 methylenetetrahydrofolate reductase (MTHFR) deficiency

Motif enrichment analysis in KO cells showed enrichment of motifs for transcription factors involved in TGF- signaling activation, such as JUN ( AP-1 ) and SMAD Family Member 3 ( SMAD3 ) 53 , as well as Forkhead Box P3 ( FOXP3 ), which is crucial for TGF--mediated regulatory T cell differentiation and immune tolerance 54

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