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In vitro and rodent data show it stimulates collagen and glycosaminoglycan synthesis, activates matrix metalloproteinase remodeling pathways, and upregulates antioxidant enzymes including superoxide dismutase and catalase [1]

Severe cases of b12 overdose level may cause high blood pressure or heart palpitations

*Correspondence: Agata Blazewicz, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Selenite can be reduced to selenide and elemental Se by the action of TXNRD1 (Kumar et al., 1992), an essential selenoprotein ranking high in the selenoprotein hierarchy (Kuhbacher et al., 2009)