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(2021) 35(9):e21864

This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings

In addition, B

P21 reverses this architectural damage while simultaneously generating new neurons to replace those lost entirely

In this period, neurons that fail to receive trophic support die by apoptosis (Burek and Oppenheim, 1996), a type of cell death also commonly observed in neurodegenerative diseases (Kirkland and Franklin, 2003