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A phase 3 RAINFALL study of ramucirumab plus a fluoropyrimidine and cisplatin or placebo plus a fluoropyrimidine and cisplatin (67) showed statistical significance in the primary analysis of mPFS, but the results were not confirmed in a sensitivity analysis of progression-free survival by central independent review because the results of mOS were not statistically significant

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The final classification framework included six primary categories corresponding to clinical study processes: patient recruitment, digital treatment, data monitoring and collection, outcome assessment, remote follow-up, and long-term care management

however, some studies indicate that moderate hyperosmolarity (around 400 mOsm) may promote the differentiation of AD-MSCs and BMSCs towards a chondrogenic phenotype and upregulate markers such as collagen II and aggrecan (Zhang Y