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The low detection accuracy of in vivo imaging, caused by interference from free iron, parallels the translational paradox seen in clinical trials of iron chelators such as deferoxamineeffective in animals but ineffective in humansrevealing that a coordinated validation system linking molecular targets, imaging evaluation, and clinical efficacy is still lacking

doi: 10.13194/j.issn.1673-842x.2023.07.026 39 DunneCO'MahonyLMurphyLThorntonGMorrisseyDO'HalloranSet al

Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM

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