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In mature erythrocytes, PKC induces eryptosis by stimulating Ca 2+ signaling [255, 256]

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Since the first report describing the physiological role of ABCB6 as a transporter of porphyrin metabolites 4 , several studies have revealed its ability to interact with diverse substrates including heavy metals 13,14,22,23 and organic compounds such as tomatine hydrochloride (responsible for defense against plant pathogens) and vertporfin (a drug used as a sensitizer for photodynamic therapy to remove abnormal blood vessels in the eyes) 15

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Lynch S.V., Pedersen O