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ROS promotes the formation of caspase-1, caspase-3, and caspase-4/5, which generate active N-terminal domains through the hydrolysis of Gasdermin D (GSDMD), ultimately leading to hepatoma cell membrane perforation and rupture [123]

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10.1007/s12035-015-9602-7 241 StamelouM.TuschlK.ChongW

They are also shown to be used for the treatment of cancer, as well as in the treatment of cystic fibrosis, rheumatoid arthritis, acne, and psoriasis

Upon activation by conditions inducing ER stress, CHAC1 expression is upregulated primarily through the PERK-eIF2-ATF3/4 signaling pathway, independent of other UPR branches like IRE1-XBP1