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Moreover, such endogenous brain proteins, cross-seeded to induce aggregation into toxic oligomers, could become the pernicious species responsible for growth of slowly expanding lesions in progressive MS, or form tiny islands of deposited seed to which microglia react to form nodules in pre-lesions

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Homeostatic strengthening of inhibitory synapses is mediated by the accumulation of GABA A receptors

The needle dulls after one use, the lubricant coating degrades, and the sterility is compromised